Female Sex Selection Using Clomiphene Citrate and Albumin

Abstract Background – This study was undertaken to assess whether the use of clomiphene citrate in conjunction with albumin-separated sperm will alter the sex ratio, proportion of males, towards females and if this skewing is due solely to induction of ovulation. Methods – The sex ratios of 184 single and 42 twin births born at 5 assisted reproductive biology clinics were determined.  The normal approximation to the binomial distribution was used to determine significant differences between these sex ratios and the established sex ratios for single, twin and combined (single and twin) non- and ovulation induced births. Results – The non-induced ovulation sex ratio for singletons (51.4%) and twins (50.2%) were greater than the treatment singleton (27.7%; P < 0.001) and twin sex ratios (33.3%; P < 0.01), respectively.

Correspondingly, the non-induced sex ratio for combined (51.4%) births was greater than the treatment sex ratio (28.8%; P < 0.001).  The induced singleton and twin sex ratios (48.1%) were lower than the non-induced sex ratio (51.4%), but higher than the treatment singleton (27.7%; P < 0.001) or twin (33.3%; P < 0.03) sex ratios.  The induced combined (48.1%) was less than the non-induced combined (51.4%) sex ratio, although greater than the treatment combined sex ratio (28.8%; P < 0.001).